Retatrutide is a experimental peptide designed to help with weight loss and metabolic health. It works by activating three key hormone receptors: GLP-1, GIP, and glucagon, which together help control blood sugar, reduce appetite, and increase energy use. Early studies show that Retatrutide may lead to greater weight loss and better blood sugar control than current treatments like semaglutide or tirzepatide. It is given as a once-weekly injection under the skin and has shown promising results in clinical trials so far.
Retatrutide
Dosing Guidance
The standard weekly dose of Retatrutide ranges from 0.5mg-4mg, over the course of 12 to 16 weeks. Usually, 0.5 mg doses are administered from weeks 1-4, with the dosage doubling every 4 weeks.
An advanced weekly dose of Retatrutide ranges from 2mg-12mg over the course of 12 to 16 weeks. The recommended dosage doubles every 4 weeks, except for weeks 13 to 16.
Standard Dosing Protocol:
0.5mg-4mg, 1x Week, 4-16 Weeks
Reconstitute with 2 mL of bacteriostatic water to create a 5.0 mg/mL solution.
1. Draw 2.0 mL of bacteriostatic water into a sterile syringe.
2. Inject the water slowly along the vial wall to reduce foam.
3. Gently swirl/roll the vial, avoid vigorous shaking.
4. To store, refrigerate the reconstituted solution at 2–8 °C, protected from light.
Advanced Dosing Protocol:
6 mg, 1x Daily, 10-Day Protocol
Reconstitute with 1 mL to create a 10 mg/mL solution (≈100 mcg per unit).
1. Draw 1mL of bacteriostatic water into a sterile syringe.
2. Inject the water slowly along the vial wall to reduce foam.
3. Gently swirl/roll the vial, avoid vigorous shaking.
4. To store, refrigerate the reconstituted solution at 2–8 °C, protected from light.
Note: If more than 10 mg per day are required, multiple injections or additional vials may be needed.